ABSTRACT
Objective To analyze the effect of butylphthalide on edema around hematoma and ambulatory blood pressure in patients with hypertensive intracerebral hemorrhage. Methods From December 2014 to February 2014, ninety-two cases of hypertensive cerebral hemorrhage patients treated in People′s Hospital of Longhua, Shenzhen were selected, the patients were divided into the control group and the study group,each with 46 cases. The control group received routine treatment. The study group was given 200 mg butylphthalide Capsule on the basis of conventional treatment,3 times /d,and 20 d for 1 course. The hematoma and surrounding edema and the changes of ambulatory blood pressure were compared between the two groups. The clinical efficacy and adverse reactions of the two groups were observed. Results Before treatment, there was no significant difference in hematoma volume, edema volume and blood pressure between the two groups ( P>0. 05) . After treatment,the hematoma volume,edema volume,24 h mean systolic pressure,24 h mean diastolic pressure,mean day systolic pressure,mean daytime diastolic pressure,mean night systolic pressure,and mean night diastolic pressure were lower than those of the control group(hematoma volume: (7. 54±1. 36) ml vs. (10. 63 ±2. 59) ml,edema volume: (4. 59±1. 35) ml vs. (7. 36±2. 14) ml,24 h mean systolic blood pressure:(125. 49±6. 34) mmHg vs. (133. 48±7. 11)mmHg,24 h mean diastolic pressure: (83. 42±5. 10) mmHg vs. ( 87. 61 ± 5. 73 ) mmHg, mean daytime systolic pressure: ( 127. 83 ± 9. 51 ) mmHg vs. ( 138. 29 ±10. 21) mmHg,daytime mean diastolic pressure:(85. 36±6. 11)mmHg vs. (89. 51±6. 34) mmHg,night mean systolic pressure: ( 124. 60 ± 7. 31 ) mmHg vs. ( 135. 39 ± 7. 85 mm ) mmHg, night mean diastolic pressure:(82. 24±5. 14) mmHg vs. ( 87. 53 ± 5. 70 mm) mmHg, the differences in the two groups were statistically significant ( t=20. 691,28. 816,5. 689,3. 705,5. 085,3. 197,6. 823,4. 675,P<0. 05); the effective rate of the study group was 91. 30％ ( 42/46) ,and the control group was 73. 91％ ( 34/46) ,and the difference between the two groups was statistically significant (χ2 = 4. 842, P<0. 05 ) . There was no significant difference in the incidence of adverse reactions between the two groups ( P>0. 05 ) . Conclusion Butylphthalide is effective in treating hypertensive intracerebral hemorrhage. It can effectively improve edema around the hematoma and dynamic blood pressure.